Custom Synthesis
Chromatogen Analytical Laboratory offers specialized custom synthesis services to support the pharmaceutical, biotech, and fine chemical industries. By combining our advanced multi-step organic synthesis capabilities with our premier in-house analytical infrastructure (NMR, HRMS, and GC-MS), we provide high-purity reference materials, target molecules, and critical chemical building blocks tailored exactly to your technical specifications.
Core Synthesis Capabilities
Our chemistry team specializes in designing efficient synthetic routes for complex, low-volume organic molecules, ensuring strict quality control from raw materials to final characterization.
1. Impurity & Degradant Synthesis
Novel Impurities: De novo synthesis of process-related impurities, potential degradants, and bypass products identified during stability testing.
Isomers & Related Substances: Isolation and synthetic replication of structural isomers, regioisomers, and complex related substances.
Stable Labelled Compounds: Custom preparation of stable isotope-labelled references for ultra-trace quantification.
2. Reference Standards & Building Blocks
Working Standards: Custom synthesis and structural qualification of reference standards missing from commercial repositories (USP, IP, EP).
Key Intermediates: Small-scale synthesis of advanced synthetic intermediates and key starting materials (KSMs) to support early-stage route scouting.
Specialty Fine Chemicals: Tailored organic molecules, building blocks, and functional derivatives ranging from milligram to multi-gram scales.
The Chromatogen Advantage: Integrated Analysis & Synthesis
Unlike standard chemical suppliers, Chromatogen bridges the gap between synthesis and absolute analytical characterization. Every custom molecule synthesized at our Mysuru facility undergoes rigorous multi-platform testing before release.
In-House Structural Confirmation: Immediate structural validation using our high-resolution Nuclear Magnetic Resonance (NMR) and High-Resolution Mass Spectrometry (HRMS) instruments.
Certified Purity Reports: Delivery of comprehensive Certificates of Analysis (CoA) containing complete chromatographic purity metrics via HPLC-DAD/ELSD or GC-FID.
Rapid Iteration Loops: Our synthetic chemists collaborate directly with our analytical experts in real time, dramatically shrinking route scouting timelines and optimizing step conversions.
Industry Applications
Our custom synthesis infrastructure is optimized to support research teams at various points in their development pipelines:
Pharmaceutical R&D: Accelerating discovery phases with fast-turnaround synthesis of unknown process impurities and degradation products.
Regulatory Compliance & CMC: Providing certified reference materials required for complete impurity profiling in critical regulatory filings.
Specialty Chemicals & Academic Research: Serving as a reliable source for custom-tailored organic substrates and complex target molecules.
The Chromatogen Advantage: Integrated Analysis & Synthesis
Uncompromising Purity. Absolute Structural Certainty.
At Chromatogen, we deliver more than just a chemical compound. We provide completely characterized, high-purity materials backed by definitive analytical data packages, ensuring seamless integration into your testing, scale-up, and regulatory workflows.